Proven, Effective, Low Cost Treatment for A Leading Cause of Hospitalization and Death Ignored…Why?
You need to know about an effective treatment for a
condition that according to the CDC, impacts more than 1.5 million Americans
annually; a quarter of a million die from it each year and a third of patients
who die in a hospital have this condition. It could save your life or a loved
Despite these staggering numbers, most people have never
heard of sepsis.
Last week, while Skyping with my godson, who recently began
his residency (junior doctor) training in the UK, he shared with me a harrowing
case of a seriously ill patient, with a suspected and later proven cases of
sepsis (a life endangering infection), I shared with him a very promising study
I’d discovered earlier this year, about a proven, effective and low cost
treatment, that remains unknown and overlooked. I’m excited to share this info
Sepsis is a
condition caused by an invading bacteria, that includes severe damage,
primarily caused by an uncontrollable response, that causes severe cellular
damage, characterized by oxidative damage, hyper-inflammation, immune
dysfunction, low oxygen levels, increased blood coagulation, usually caused by
an infectious agent.
When susceptible persons are infected, there can be an
uncontrolled severe response by the immune system inflammatory
response that disrupts organ function and blood flow.
Instead of targeting the offending
bacteria or virus, the immune system mounts inflammatory
reactions that can result in circulatory collapse, multi-organ failure, and
What you need to know
Sepsis is a life-threatening medical condition, affecting
approximately 26 million people worldwide every year. The disease is a
continuum, with uncontrollable inflammation, instability of blood vessels,
leading to shock, organ dysfunction and failure, and ultimately death.
Medical treatment has focused on the early identification
and treatment of sepsis primarily with bundled and goal directed therapy.
Despite these advances, complications and death has remained high, and led to
investigating unique therapies.
Vitamin C is a water-soluble vitamin that plays a role in
managing inflammation through antioxidant activities and is also important in
the synthesis of cortisol, catecholamines, and vasopressin, which are key
mediators in the disease process. A growing body of evidence provides initial
data in support of the administration of vitamin C in addition to standard
therapy to ameliorate the effects of inflammation and improve hemodynamic
stability in patients with sepsis and septic shock; however, further evidence
is needed to support this practice.
There is an urgent need to find better treatments for
sepsis, as it causes approximately 250,000 American deaths each year. A recent
clinical study has revealed that a combination therapy with vitamin C was able
to dramatically lowered death from septic shock compared to current treatment.
In a study published in 2017, a group of
47 hospitalized sepsis patients were treated with intravenous vitamin
C, hydrocortisone, and vitamin B1.
Compared to sepsis patients treated with conventional
therapy, those receiving the intravenous vitamins and hydrocortisone
had a striking 87% reduced mortality.4
These impressive small-scale studies have ignited eight
new clinical trials in 2018 that will use
this three-prong approach, i.e., intravenous vitamin C, vitamin
B1, and hydrocortisone.
Tragically this particular treatment approach was
documented several decades ago As you’re about to learn, this kind of approach
to sepsis treatment was demonstrated in the late nineties. Millions
may have needlessly succumbed because this therapy was overlooked by the
It described the staggering costs of hospitalized sepsis
patients, along with better ways to treat sepsis that had been
published in the 1990s.
Move forward 20 years and virtually none
of those published methods to save sepsis patients have been
adopted into hospital practice.
Sepsis is a
frustrating condition to offer suggestions for from the outside. That’s because
the septic patient is confined to a hospital, where the treating physician
exerts dictatorial authority.
There has been fierce hostility by many physicians against
the use of intravenous vitamins in the hospital setting,
despite persuasive evidence of efficacy. This prejudice may soon change.
Pioneering ICU Doctor Defies Conventional Wisdom
If you happen to reside anywhere near Norfolk, Virginia,
and require hospitalization, you may want to enroll as a patient of Dr.
Paul Marik at Sentara Norfolk General Hospital.
Dr. Marik has incorporated intravenous vitamins
+ hydrocortisone therapy into routine treatment of sepsis.
Patients threatened with death are instead leaving the hospital alive within
According to Dr. Paul Marcik noted, “Our experience has
been echoed by now hundreds, if not thousands, of clinicians across the world,”
said Dr. Marik, chief of the division of pulmonary and critical care medicine,
Eastern Virginia Medical School, Norfolk.
Local media are reporting on Dr. Marik’s “miracle
juice,” quoting an ICU nurse:18
“We started having patient after patient have these
remarkable results…They’d be at death’s door and, 24 to 48 hours later, they
had turned around. We have seen patients walk out of here we didn’t think would
Critics state that full blown clinical trials involving
large numbers of septic patients are required to prove this therapy is really
Dr. Marik agrees, but initially noted it may be difficult
to fund large studies because it uses a drug
(hydrocortisone) and vitamins that have been on the market for
decades. Dr. Marik was quoted earlier this year:18
“We are curing (sepsis) for $60. No one will make
any money off it.”
He also informed Life Extension magazine that over 700
American patients have now been treated with consistent response. He stated
there was no evidence of side effects in thousands of patients treated around
the world using his protocol of intravenous vitamin C, thiamine
When asked if additional nutrients or drugs might provide
greater benefits, Dr. Marik replied:
“I believe that our current combo is safe, cheap and
very effective…so it’s difficult to beat this.”
He went on to state that there are three
new clinical trials using his protocol underway or about to begin in the United
States and another five around the world are beginning.
The good news is that new studies using this protocol are
being launched this year, despite there being no blockbuster new drug involved.
Low Vitamin C in Sepsis Patients
A study published in 2017 looked at vitamin
C plasma levels in sepsis patients.
This study found overall that critically ill sepsis
patients had low vitamin C levels with one-third having frank vitamin
Nearly 40% of septic shock
patients in this study were deficient in vitamin C compared to
25% of non-septic patients. (Septic shock is severe sepsis
that often precedes death.)
This misconception is startling when considering
hospitalized patients rapidly use up their vitamin C to suppress
acute oxidative reactions brought on by sepsis-induced inflammation.
This finding was initially reported more than 20 years
A 2018 published report titled “Vitamin
C: The next step in sepsis management?” describes mechanisms
through which vitamin C functions to suppress inflammation
and oxidation while improving blood flow to
In 2018, y there are eight new clinical
trials that will study the effects of intravenous vitamin C, thiamine,
and hydrocortisone in sepsis patients. Funding
is coming largely from philanthropic donors.
Hydrocortisone + Vitamin C = Synergy
2017 published study involving sepsis
patients were given intravenous vitamin C, vitamin B1, and the
anti-inflammatory drug hydrocortisone.
This study showed only four of 47
(8.5%) septic patients treated with these vitamins
(+ hydrocortisone) died compared to 19 of 47
(40.4%) of historic controls. This represents a remarkable 87%
reduction in death
Also, this study found the Sepsis-Related Organ
Failure Assessment score decreased in all patients in the treatment
group (vitamins + hydrocortisone). None of these treated patients developed
progressive organ failure.
Patients in the treatment group were
weaned off a class of drug used to support blood pressure
(vasopressors) 18 hours after starting the vitamins +
on the other hand, needed these blood pressure-boosting drugs
for about 54 hours…three times longer than the group treated
with intravenous vitamins + hydrocortisone.4
(Vasopressors constrict blood vessels and thereby boost
dangerously low blood pressure.)
Why Hydrocortisone + Vitamins Are Effective
The same researchers who showed remarkable survival
improvements (87% better) in human sepsis patients sought to
clarify why vitamin C + hydrocortisone was so effective in
These researchers pursued answers by identifying lethal process
of sepsis including blood vessel lining (endothelial) dysfunction
and capillary leakage.
Using endothelial cells from human lungs,
the researchers were able to identify how vitamin C and Hydrocortisone together enable more potent protective effects against inflammatory
damage to vascular cells.
This finding showed that vitamin C or hydrocortisone
alone was not satisfactory. But when combined before or after inflammation
was induced, vitamin C + hydrocortisone demonstrated a
dramatic reversal of loss of vascular barrier function, i.e., capillary
The ability of vitamin C to protect
against capillary leakage should not be surprising since that
is a critical role this nutrient plays in a healthy body.
Death by scurvy (severe vitamin C
deficiency) often comes from massive internal bleeding as the scurvy victim’s
vasculature can no longer contain blood volume.15
A paper published in 2017 describes prior
studies in animal and experimental models of sepsis, which demonstrate the
ability of vitamin C to protect against microvascular
dysfunction caused by the kind of systemic inflammation
that occurs in sepsis.16
With hundreds of thousands of Americans likely to die from sepsis
this year,23 and robust data indicating that large numbers can be
saved, it is beyond cruel to deny a septic patient the option of intravenous vitamin
C, thiamine plus hydrocortisone.
Economics of Sepsis Treatment
The annual cost of treating sepsis in the United States is $23
billion.24 Sepsis treatment is a huge revenue driver for
Patients who present or contract sepsis are confined to the
ICU for days, weeks or months, often on ventilators and receiving multiple IVs.
Hospitals can bill Medicare and insurance companies
hundreds of thousands of dollars for each septic patient.
There is now a way for people with symptoms that indicate
sepsis to potentially prevent it, possibly utilizing intravenous vitamin
C and thiamine in outpatient infusion centers.
Even if one is contracting the flu or other
infections/trauma, these nutrients may help protect against short- and
long-term tissue damage inflicted by inflammation-induced
oxidative stress, while improving immune responses.
For those who develop sepsis, Dr. Marik’s protocol of
intravenous vitamin C, thiamine plus hydrocortisone
may enable most to leave the hospital in days instead of lingering at death’s
door for agonizing periods.
With Medicare, Medicaid
and private insurers so financially stressed, this represents
a unique opportunity to significantly slash the healthcare cost burden.
How to Avoid Becoming a Sepsis Casualty
Anyone over age 60 is likely to suffer
some degree of immune senescence leading to higher septic
risk. Sepsis can strike people of any age, however, including neonates.
In reviewing Dr. Marik’s sepsis protocol that is now being
studied in several clinical trials, an intravenous dosage
protocol administered in the hospital might consist of:
- Vitamin C: 1.5 grams (administered as an infusion over 30 to 60 minutes) every six
hours for four days or until ICU discharge;
- Thiamine: 200 mg every 12 hours for four days or until ICU discharge;
- Hydrocortisone: 50 mg every six hours for seven days or until ICU discharge,
followed by a taper over three days.
The clinical presentation of sepsis is highly variable
depending on a wide range of clinically relevant factors.
Common sites of primary infection are respiratory,
genital/urinary, gastrointestinal, skin, and soft tissue.
Fever is often the first manifestation of sepsis, with
pneumonia being one of the most common presentations leading to sepsis.
Early initiation of therapy decreases in-hospital
mortality. Some early indicators of sepsis include:
- Hypothermia (lower than normal body temperature)
- Heart rate >90 beats per minute
- Fast respiratory rate
- Altered mental status (confusion/coma)
- Edema (swelling)
- High blood glucose (without diabetes)
Since some of these symptoms might indicate a flu virus or
other infection, it might make sense for people developing these symptoms to
load up on oral antioxidant nutrients, or ideally, go to a
local infusion center for intravenous administration of
vitamin C, vitamin B1, and possibly glutathione.
With 250,000 Americans perishing each year
from sepsis, we look forward to updating you regarding the results from clinical
trials that will study the effects of intravenous vitamin C,
thiamine and hydrocortisone on large numbers
of sepsis patients.