Canadian researchers at the University of Montreal discovered that vitamin B3 can treat drug resistant fungal infections that attack individuals with compromised immunity and can lead to death. Fungal infections that include Candida, Apsergillus are resistant to current drug therapy. This study found vitamin B3 has broad antifungal properties.
Patients with diminished immune system function, including HIV infection, those receiving chemotherapy and organ transplant recipients. Vitamin B3 in the form nicotinamide was given to mice and found to have strong properties for inhibiting the growth of Candida albicans, a form of yeast infection.
Vitamin B3 stopped the functioning of a critical Candida albicans enzyme, known as Hst3 that is essential to the growth and survival of the yeast infection and also limited the growth of Aspergillus fumigatus. Aspergillus, another fungal infection that can cause severe allergic reaction and death for patients with lowered immunity.
Vitamin B3 is equally effective for reducing the growth of both drug resistant and normal infections caused by these organism, recognizes its potential as a new approach for treatment for common hospital acquired infection that occurs in patients whose immune systems are compromised. Diabetics are particularly susceptible to yeast infections.
Martine Raymond, a professor at the University of Montreal Department of Biochemistry explains, "There is an urgent need to develop new therapies to kill C. albicans because it is one of the leading causes of hospital-acquired infections and is associated with high mortality rates."
The yeast infection Candida albicans is an opportunistic infection that takes over when immunity becomes compromised but is present normally in the body. When yeast infection enters the bloodstream it can lead to death. Aspergillosis", the fungus “has emerged as one of the most common and most feared opportunistic infections in immunocompromised patients”, making the findings that vitamin B3 could treat fungal infections important the timely.
Raymond says the findings that vitamin B3 could treat drug resistant fungal infections have fewer side effects for patients. Finding new therapies to treat infection has become a focus from researchers. The Montreal researchers have discovered that Vitamin B3 in the form of nicotinamide could be developed to treat normal and drug resistant fungal infections.
Nature Medicine 16 774–780 (2010) doi:10.1038/nm.2175