This study’s goal was to systematically review and quantitatively synthesize evidence on the location and nature of brain structural changes linked to vitamin D depletion or repletion. Despite increasing evidence arguing for an action of vitamin D in the brain, data is sparse regarding brain morphological changes related to vitamin D depletion. The retrieved association between vitamin D depletion and brain atrophy provides a scientific base for vitamin D replacement trials.

Results showed that vitamin D depletion was associated with lower brain volume.


Vitamin D and brain volumetric changes: Systematic review and meta-analysis